Knowledge Atlas
Every concept, connected.
Pick an area to explore. Every concept has its own page with a short explanation, a picture of its connections and what to learn next.
330CONCEPTS
8DOMAINS
8KNOWN GAPS
Foundations 15
Innate vs adaptive immunity, recognition, tolerance and memory.
Cells and organs 45
T and B cells, NK cells, myeloid cells and lymphoid tissues.
See all 45
- Naive CD4 T cell
- Plasma cell
- Th2 cell
- Th17 cell
- Gut microbiota
- Natural killer cell
- Mast cell
- Tfh cell
- Tumour cell
- Monocyte
- Eosinophil
- ILC2
- Memory B cell
- Granuloma
- Exhausted CD8 T cell
- Plasmacytoid dendritic cell
- Th1 cell
- Gut mucosa
- Blood
- Tumour microenvironment
- γδ T cell
- MAIT cell
- iNKT cell
- Hepatocyte
- Keratinocyte
- Liver
- Follicular dendritic cell
- Skin
- Basophil
- Myeloid-derived suppressor cell
- Memory T cell
- Thymus
- Lung
- Lymph node
- Synovium
- Bone marrow
- Spleen
- Central nervous system
- Artery wall / plaque
Molecules and receptors 84
Cytokines, antibodies, MHC, antigen receptors, PRRs, complement, checkpoints.
See all 84
- PD-1
- Complement C5 / C5a / MAC
- IL-5
- IL-13
- CTLA-4
- IgG
- MHC class I (HLA-A/B/C)
- MHC class II (HLA-DR/DQ/DP)
- TYK2
- Donor-specific antibody
- PD-L1
- FcεRI
- IFNAR1
- BAFF
- TSLP
- Complement C3
- BCMA
- IgE
- CD40 ligand (CD40L)
- IL-23
- TLR7
- IL-23R
- BCR
- TCR
- Type I interferon
- Adenosine
- CD28
- CD80/CD86 (B7)
- CD20
- CD3
- Perforin / Granzyme B
- IL-22
- Short-chain fatty acids (butyrate)
- Secretory IgA
- IL23R coding variants
- IL-12
- IL-10
- CXCL10
- GM-CSF
- NLRP3
- TNFR1
- TNFR2
- IL-6R
- IL-12 receptor
- IL-17RA
- IL-4Rα
- IL-33
- CD19
- NKG2D
- α4β7 integrin
- IL-5 receptor α
- Glucocorticoid receptor
- JAK1/JAK2
- Arginase-1 / ROS
- IL-21
- Polysaccharide A (B. fragilis)
- Microbial tryptophan / AhR ligands
- NADPH oxidase (phagocyte)
- PTPN22 R620W
- TYK2 P1104A
- CTLA4 / checkpoint gene variants
- IRF5 risk variants
- TGF-β
- CXCL8 / IL-8
- TLR4
- TLR3
- APRIL
- PD-L2
- IL-2
- MR1
- CD1d
- Histamine
- TOX
- IL-18
- Gasdermin D
- Vaccine adjuvant (alum / TLR agonist)
- BTK
- NOD2 risk variants
Signalling and mechanisms 42
Receptor signalling, inflammasomes, complement activation and migration.
- Germinal-centre reaction
- Type-I interferon signalling
- NF-κB signalling
- NLRP3 inflammasome
- JAK-STAT signalling
- T-cell receptor signalling
See all 42
- Class switching & somatic hypermutation
- Infection as innate adjuvant
- Type-2 inflammation
- Epithelial barrier breach
- Molecular mimicry
- Antigen presentation via MHC-II
- Antigen presentation via MHC-I
- V(D)J recombination
- Complement cascade
- NETosis
- Acute-phase response
- Thymic selection & central tolerance
- Peripheral Treg induction (colonic)
- Mucus / goblet barrier
- Correlate of protection
- Indirect allorecognition
- Pharmacogenetic HLA screen
- Bystander activation
- Epitope spreading
- Post-infectious flare
- Herd / indirect protection
- Th17 differentiation
- Co-stimulation (signal 2)
- T-cell exhaustion programme
- Efferocytosis & resolution
- Trained immunity
- Cancer-immunity cycle
- Dysbiosis
- Oral tolerance
- Colonisation resistance
- T follicular helper priming
- Direct allorecognition
- Operational transplant tolerance
- Ischemia–reperfusion injury
- Th1 differentiation
- cGAS-STING pathway
Not yet covered: BCR signalling · Leukocyte migration
Diseases and immunopathology 52
Autoimmunity, allergy, immunodeficiency, infection, cancer and transplant.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Inflammatory bowel disease
- Severe COVID-19 / ARDS
- Asthma
- Psoriasis
See all 52
- Multiple sclerosis
- Acute cellular rejection
- Cytokine release syndrome
- Atopic dermatitis
- SARS-CoV-2
- Atherosclerotic cardiovascular disease
- Severe combined immunodeficiency
- Tuberculosis
- Mycobacterium tuberculosis
- Candida albicans
- Type 1 diabetes
- Neuromyelitis optica spectrum disorder
- Epstein–Barr virus
- Chronic granulomatous disease
- Melanoma
- Influenza A virus
- Lupus nephritis
- Graft-versus-host disease
- Cancer immune escape
- Neisseria meningitidis
- Antibody-mediated rejection
- Chronic allograft injury
- X-linked agammaglobulinaemia
- Common variable immunodeficiency
- STAT3 loss-of-function (Hyper-IgE / Job)
- Type-I IFN sensing defect / autoantibody
- Severe cutaneous adverse reaction (SJS/TEN)
- Sepsis
- ANCA vasculitis
- Multiple myeloma
- Paroxysmal nocturnal haemoglobinuria
- Hyper-IgM syndrome
- Gout
- Terminal complement deficiency (C5–C9)
- IL-12/IFN-γ axis defect (MSMD)
- Wiskott–Aldrich syndrome
- Schistosoma species
- B-cell acute lymphoblastic leukaemia
- Heart failure
- Segmented filamentous bacteria (SFB)
- IPEX syndrome
- APECED (AIRE deficiency)
- 22q11.2 deletion (DiGeorge)
- Leukocyte adhesion deficiency type 1
- Axial spondyloarthritis / AS
- Coeliac disease
Therapies and applications 66
Biologics, small molecules, checkpoint inhibitors, cell therapies, vaccines.
See all 66
- Pembrolizumab
- Corticosteroid
- Rituximab
- Ocrelizumab
- Teplizumab
- Cilta-cel
- Abatacept
- Eculizumab
- Live attenuated vaccine
- Tocilizumab
- Nivolumab
- Baricitinib
- Anifrolumab
- Belimumab
- Deucravacitinib
- Canakinumab
- Mepolizumab
- Etanercept
- CANTOS
- Inebilizumab
- Tezepelumab
- Ipilimumab
- Vedolizumab
- Colchicine
- CheckMate 067
- Inactivated / killed vaccine
- Immunoglobulin replacement (IVIG/SCIG)
- CD19 CAR-T (autoimmune)
- Adalimumab
- KEYNOTE-006
- Omalizumab
- RAVE
- ORATORIO
- TN10 Teplizumab
- RECOVERY
- Calcineurin inhibitor
- TOWER
- Conjugate / subunit vaccine
- Mucosal vaccine (intranasal / oral)
- Antithymocyte globulin
- Ustekinumab
- ATTRACT
- ERASURE
- LIBERTY AD
- CARTITUDE-4
- Anakinra
- LIBERTY ASTHMA QUEST
- COLCOT
- Lenercept in MS
- Secukinumab in Crohn disease
- ATTACH
- MENSA
- N-MOmentum
- GEMINI 1
- TULIP-2
- BLISS-52
- NAVIGATOR
- POETYK PSO-1
- PNH eculizumab (TRIUMPH)
- TGN1412 first-in-human
Research methods 36
Assays, sequencing, models and translational research.
- GWAS & HLA genetics
- C-reactive protein (CRP)
- ANCA
- Neutralising antibody titre
- HLA-DRB1 shared epitope
- Interferon-stimulated gene signature
See all 36
- Anti-dsDNA antibody
- ACPA
- HLA-B*27
- HLA-DRB1*15:01
- PD-L1 expression
- Blood eosinophil count
- Ferritin
- FeNO
- BSRBR-RA registry
- Single-cell RNA-seq atlases
- HLA-DQ2 / DQ8
- HLA-B*57:01
- HLA-B*15:02
- Erythrocyte sedimentation rate (ESR)
- Faecal calprotectin
- Serum IgE
- Tryptase
- TMB
- Anti-AQP4 antibody
- Islet autoantibodies
- Electronic health records
- Spatial transcriptomics
- Longitudinal military cohort (EBV)
- scGPT
- KG traversal
- Immune digital twin
- Generative AI drug discovery
- Structure prediction (AlphaFold-class)
- Crossmatch / DSA screen
- HLA-C*06:02
Not yet covered: Flow cytometry · ELISA and immunoassays · Immunohistochemistry · Experimental models
Research intelligence 5
Discoveries, emerging mechanisms and open questions.
- EBV infection precedes MS
- FOLR2+ tissue-resident macrophages
- CD19 CAR-T resets refractory SLE
- Residual inflammatory risk in CVD
- TNIK inhibition for IPF
Not yet covered: Recent publications · Conflicting evidence