Biomarker
Interferon-stimulated gene signature
Gene-expression pattern reflecting interferon pathway activity.
Also called: IFN signature, interferon-stimulated gene signature, ISG score, type I IFN signature
In short
- 1What it is: a biomarker in research methods.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 molecule, 1 pathway, 1 therapy.
- 3Where it sits: biomarker, failure, target on the 15-step immune chain.
What it does
75% of SLE patients IFN-signature-high; predicts anifrolumab response (TULIP-1/2: IFN-high patients show greater BICLA response); AI single-cell discovery: ISG15+ macrophage subpopulation is exclusive to Class III/IV lupus nephritis (explains why anifrolumab works in proliferative but not membranous LN); interferon score also elevated in Sjögren's, dermatomyositis, systemic sclerosis
Its connections at a glance
Each dot is a concept directly linked to Interferon-stimulated gene signature. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID B005 · concept status: established. Select any connection above to inspect evidence for that specific link.