Disease
Inflammatory bowel disease
Chronic intestinal inflammation including Crohn disease and ulcerative colitis.
Also called: IBD, Crohn's disease, UC, ulcerative colitis, inflammatory bowel disease
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 10 concepts — mostly 3 molecule, 2 pathway, 5 therapy.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Th17/ILC3 → IL-17A mucosal; macrophage IL-6/TNF transmural (CD); SEQUENCE trial (2023): risankizumab vs ustekinumab → 45% vs 33% remission in CD; U-EXCEED: upadacitinib 45mg vs adalimumab → 39% vs 22% remission (first JAK inhibitor superiority over anti-TNF in CD); F.
Its connections at a glance
Each dot is a concept directly linked to Inflammatory bowel disease. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D004 · concept status: established. Select any connection above to inspect evidence for that specific link.