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Pathogen

SARS-CoV-2

Respiratory coronavirus eliciting innate and adaptive immune responses.

Also called: SARS-CoV-2, COVID-19, coronavirus

Ask about SARS-CoV-2 See in graph Sources

In short

  1. 1What it is: a pathogen in diseases and immunopathology.
  2. 2How it connects: acts on 2 and is affected by 3 concepts — mostly 3 cell, 1 pathway, 1 disease.
  3. 3Where it sits: trigger on the 15-step immune chain.

What it does

RIG-I/MDA5 + TLR7 → type I IFN antiviral response (early phase); severe disease: monocyte-derived macrophage IL-6 storm → ARDS (cytokine phase); RECOVERY trial: dexamethasone beneficial only in oxygen-requiring (cytokine phase), harmful in non-oxygen-requiring (viral replication phase, immune suppression worsens viral clearance)

Its connections at a glance

Each dot is a concept directly linked to SARS-CoV-2. Colours show the kind of concept.

Conventional dendriti…CD8 cytotoxic T lymph…MAIT cellSevere COVID-19 / ARDSInfection as innate a…SARS-CoV-2

Learn next

Comes beforeConventional dendritic cellCellComes beforeCD8 cytotoxic T lymphocyteCellComes beforeMAIT cellCellLeads toSevere COVID-19 / ARDSDiseaseLeads toInfection as innate adjuvantPathway
Sources & evidenceloading…

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Graph ID X005 · concept status: established. Select any connection above to inspect evidence for that specific link.