Pathway
T-cell exhaustion programme
Chronic TCR stimulation → NFAT without AP-1 → TOX → inhibitory receptor expression and loss of effector function.
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 1 and is affected by 1 concepts — mostly 1 cell, 1 receptor.
- 3Where it sits: failure on the 15-step immune chain.
Its connections at a glance
Each dot is a concept directly linked to T-cell exhaustion programme. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P015 · concept status: evidence-supported. Select any connection above to inspect evidence for that specific link.