Pathway
Th1 differentiation
Differentiation programme associated with IL-12/STAT4/T-bet biology.
Also called: Th1 differentiation, Th1 polarisation, T-bet pathway
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 0 and is affected by 1 concepts — mostly 1 receptor.
- 3Where it sits: signalling, response on the 15-step immune chain.
What it does
IL-12→IL-12R→JAK2/TYK2→STAT4→T-bet → IFN-γ production; drives intracellular pathogen immunity (TB) and autoimmune Th1 disease (RA, T1DM, MS)
Its connections at a glance
Each dot is a concept directly linked to Th1 differentiation. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID P009 · concept status: established. Select any connection above to inspect evidence for that specific link.