Therapy
Infliximab
Monoclonal antibody targeting TNF.
Also called: infliximab, Remicade, IFX
In short
- 1What it is: a therapy in therapies and applications.
- 2How it connects: acts on 4 and is affected by 2 concepts — mostly 1 molecule, 2 disease, 1 therapy.
- 3Where it sits: therapy, trial on the 15-step immune chain.
What it does
Chimeric IgG1; binds soluble AND membrane TNF → reverse signalling → macrophage/T cell apoptosis in granuloma → fistula healing in CD (etanercept cannot); ATTRACT trial (2000): first biologic to show structural protection in RA; risk: TB reactivation (mandatory LTBI), infusion reactions (slow first infusion), anti-drug antibodies (minimised by concomitant MTX); TDM: trough >3-7 μg/mL for mucosal healing in IBD
Its connections at a glance
Each dot is a concept directly linked to Infliximab. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID I001 · concept status: established. Select any connection above to inspect evidence for that specific link.