Tissue
Skin
Barrier tissue with resident immune sentinels.
Also called: skin, dermis, epidermis, cutaneous
In short
- 1What it is: a tissue in cells and organs.
- 2How it connects: acts on 1 and is affected by 1 concepts — mostly 1 cell, 1 disease.
- 3Where it sits: patient on the 15-step immune chain.
What it does
Epicutaneous sensitisation (FLG mutation → skin barrier defect → pollen/peanut/mite sensitisation through skin → IgE → systemic allergy); LL-37+dsDNA NET complexes in psoriatic skin → pDC TLR9 → IFN-α → DC maturation → Th17 amplification; target of dupilumab (AD), secukinumab (psoriasis)
Its connections at a glance
Each dot is a concept directly linked to Skin. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID T001 · concept status: established. Select any connection above to inspect evidence for that specific link.