Disease
Rheumatoid arthritis
Chronic inflammatory arthritis involving TNF, IL-6 and other inflammatory pathways.
Also called: RA, rheumatoid arthritis
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 3 and is affected by 10 concepts — mostly 3 molecule, 2 pathway, 1 tissue.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Dominant drivers: CD4+ Th1/Th17 synovitis + ACPA-producing GC B cells + synovial macrophage M1 (TNF/IL-6/RANKL); HLA-DRB1 SE → citrullinated protein presentation; ACPA+ RA may respond better to abatacept (observational data); R4RA AI pathotyping → rituximab (lymphoid) vs tocilizumab (myeloid)
Its connections at a glance
Each dot is a concept directly linked to Rheumatoid arthritis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D001 · concept status: established. Select any connection above to inspect evidence for that specific link.