Biomarker
TMB
Tumour mutational burden: total number of somatic mutations per megabase of coding sequence, quantified by tissue NGS (FoundationOne CDx, FDA-approved biomarker).
Also called: tumour mutational burden, TMB-H, somatic mutation rate
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a biomarker in research methods.
- 2How it connects: acts on 0 and is affected by 1 concepts — mostly 1 disease.
- 3Where it sits: biomarker, target on the 15-step immune chain.
What it does
FDA approved pembrolizumab for TMB-H ≥10 mut/Mb solid tumours (tumour-agnostic, 2020; KEYnote-158).
Its connections at a glance
Each dot is a concept directly linked to TMB. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
Loading reviewed sources…
Graph ID B010 · concept status: established. Select any connection above to inspect evidence for that specific link.