Molecule
GM-CSF
Myeloid differentiation and inflammatory activation factor.
Also called: GM-CSF, granulocyte-macrophage CSF, CSF2
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 1 concepts — mostly 2 cell.
- 3Where it sits: signalling, response on the 15-step immune chain.
What it does
Myeloid differentiation and activation; elevated in RA synovium; target of otilimab (anti-GM-CSF, Phase 3 RA); therapeutic G-CSF (filgrastim/lenograstim) mobilises HSCs from bone marrow for HSCT collection
Its connections at a glance
Each dot is a concept directly linked to GM-CSF. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M015 · concept status: established. Select any connection above to inspect evidence for that specific link.