Pathway
V(D)J recombination
RAG1/RAG2 endonuclease-mediated combinatorial joining of Variable, Diversity, and Joining immunoglobulin/TCR gene segments + N-nucleotide addition at junctions → 10^15-18 receptor diversity.
Also called: VDJ recombination, RAG recombination, immune repertoire generation
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 2 receptor, 1 disease.
- 3Where it sits: recognition on the 15-step immune chain.
What it does
RAG1/RAG2 mutations → RAG-SCID (no T or B cells, no V(D)J recombination); CAR-T bypasses this system (synthetic antigen receptor).
Its connections at a glance
Each dot is a concept directly linked to V(D)J recombination. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P012 · concept status: established. Select any connection above to inspect evidence for that specific link.