Cell
Th1 cell
Cell-mediated immunity; associated with IFN-γ production.
Also called: Th1 cell, T helper 1
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 cell, 2 molecule.
- 3Where it sits: response, failure, target on the 15-step immune chain.
What it does
IFN-γ → macrophage M1 activation → intracellular pathogen killing; drives RA synovitis, T1DM insulitis (nPOD dominant cell), MS CNS inflammation; teplizumab (anti-CD3 Fc-silent) shifts Th1:Treg ratio in T1DM islets → TN10 trial: 25-month T1DM onset delay (FDA 2022, first autoimmune prevention drug)
Its connections at a glance
Each dot is a concept directly linked to Th1 cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C011 · concept status: established. Select any connection above to inspect evidence for that specific link.