Cell
B cell
Antigen-recognizing lymphocyte that can differentiate into antibody-secreting cells.
Also called: B lymphocyte, B cell, naive B cell, germinal centre B cell
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 6 and is affected by 10 concepts — mostly 4 cell, 2 molecule, 2 receptor.
- 3Where it sits: response, failure, target on the 15-step immune chain.
What it does
V(D)J recombination → 10^12 BCR diversity; GC → AID-driven SHM + class switching; produces ANCA (vasculitis), ACPA (RA), anti-dsDNA (SLE), OCBs (MS); CD20+ → depleted by rituximab/ocrelizumab BUT plasma cells are CD20-negative and missed
Its connections at a glance
Each dot is a concept directly linked to B cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C017 · concept status: established. Select any connection above to inspect evidence for that specific link.