Disease
Sepsis
Dysregulated host response to infection with organ dysfunction.
Also called: sepsis, septicaemia, systemic sepsis
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 0 and is affected by 2 concepts — mostly 2 molecule.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Dysregulated host response to infection; macrophage/monocyte → TNF/IL-1β/IL-6 storm → endothelial activation → DIC → MOF; Surviving Sepsis Campaign bundles; anti-TNF failed in sepsis trials (TNF has context-dependent protective roles); IL-6R blockade also failed in bacterial sepsis; different from COVID-19 ARDS where IL-6R blockade works
Its connections at a glance
Each dot is a concept directly linked to Sepsis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D011 · concept status: established. Select any connection above to inspect evidence for that specific link.