Cell
Naive CD4 T cell
Antigen-specific helper T-cell precursor.
Also called: naive CD4+ T cell, CD4+ naive T cell
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 5 and is affected by 5 concepts — mostly 4 cell, 1 receptor, 3 pathway.
- 3Where it sits: recognition, response on the 15-step immune chain.
What it does
Receives Signal 1 (TCR-pMHC) + Signal 2 (CD28-B7) + Signal 3 (cytokine context) → subset fate; Signal 1 without Signal 2 → anergy (peripheral tolerance mechanism); abatacept (CTLA-4-Ig) blocks Signal 2 → T cell anergy in RA (observational data suggest better response in anti-CCP+ RA)
Its connections at a glance
Each dot is a concept directly linked to Naive CD4 T cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C010 · concept status: established. Select any connection above to inspect evidence for that specific link.