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Cell

Conventional dendritic cell

Professional antigen-presenting cell that efficiently primes naive T cells.

Also called: cDC, cDC1, cDC2, dendritic cell

Ask about Conventional dendritic cell See in graph Sources

In short

  1. 1What it is: a cell in foundations.
  2. 2How it connects: acts on 4 and is affected by 7 concepts — mostly 1 molecule, 1 receptor, 4 pathway.
  3. 3Where it sits: recognition, response on the 15-step immune chain.

What it does

cDC1 cross-presents tumour neoantigens to CD8 CTL (requires cGAS-STING activation); absent cDC recruitment = cold tumour (WNT/β-catenin suppresses CCL4→DC axis); STING agonists (diABZI) force cDC maturation; adjuvants force DC maturation (AS01B → TLR4+NLRP3 → Shingrix 91% efficacy ≥70y)

Its connections at a glance

Each dot is a concept directly linked to Conventional dendritic cell. Colours show the kind of concept.

Cancer-immunity cycleVaccine adjuvant (alu…mRNA vaccineConjugate / subunit v…Inactivated / killed …Mucosal vaccine (intr…Infection as innate a…Antigen presentation …Antigen presentation …SARS-CoV-2MHC class II (HLA-DR/…Conventional dendritic cell

Learn next

Comes beforeCancer-immunity cyclePathwayComes beforeVaccine adjuvant (alum / TLR agonist)MoleculeComes beforemRNA vaccineTherapyLeads toAntigen presentation via MHC-IIPathwayLeads toAntigen presentation via MHC-IPathway
Sources & evidenceloading…

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Graph ID C004 · concept status: established. Select any connection above to inspect evidence for that specific link.