Cell
ILC2
Innate lymphoid cell producing type-2 cytokines at barrier tissues.
Also called: ILC2, innate lymphoid cell 2
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 1 and is affected by 3 concepts — mostly 3 molecule, 1 disease.
- 3Where it sits: trigger, response, target on the 15-step immune chain.
What it does
Responds to TSLP/IL-25/IL-33 without antigen-specific receptor; drives type-2 asthma even without Th2 cells (explains why IL-5 blockade fails in non-Th2 asthma); target of tezepelumab (anti-TSLP → broadest asthma efficacy NAVIGATOR: 56% exacerbation reduction across ALL endotypes including low-eosinophil)
Its connections at a glance
Each dot is a concept directly linked to ILC2. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C009 · concept status: established. Select any connection above to inspect evidence for that specific link.