Receptor
CD28
Constitutive T-cell co-stimulatory receptor; binding CD80/CD86 delivers signal 2 via PI3K–AKT.
In short
- 1What it is: a receptor in foundations.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 1 receptor, 1 pathway, 1 trial.
- 3Where it sits: recognition, signalling on the 15-step immune chain.
What it does
TGN1412 (CD28 superagonist) caused a cytokine storm in the 2006 first-in-human study.
Its connections at a glance
Each dot is a concept directly linked to CD28. Colours show the kind of concept.
Sources & evidenceloading…
Loading reviewed sources…
Graph ID R019 · concept status: established. Select any connection above to inspect evidence for that specific link.