Molecule
IL-17A
Barrier inflammatory cytokine that supports neutrophil-associated host defence.
Also called: IL-17A, interleukin-17A, IL17A
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 4 and is affected by 4 concepts — mostly 3 cell, 1 receptor, 3 disease.
- 3Where it sits: signalling, consequence, target on the 15-step immune chain.
What it does
IL-17RA+IL-17RC → NF-κB+MAPK → CXCL8 (neutrophil chemokine), antimicrobial peptides, keratinocyte hyperproliferation; gut barrier tight junction maintenance; Absolute contraindication: active IBD (blockade → tight junction loss → bacterial translocation → IBD flare).
Its connections at a glance
Each dot is a concept directly linked to IL-17A. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M010 · concept status: established. Select any connection above to inspect evidence for that specific link.