Therapy
Corticosteroid
Drug class that suppresses multiple inflammatory gene programmes.
Also called: corticosteroids, glucocorticoids, prednisone, prednisolone, dexamethasone, methylprednisolone
In short
- 1What it is: a therapy in therapies and applications.
- 2How it connects: acts on 4 and is affected by 1 concepts — mostly 1 receptor, 1 pathway, 2 disease.
- 3Where it sits: therapy on the 15-step immune chain.
What it does
GR → NF-κB suppression (IκBα induction → sequesters NF-κB) + AP-1 suppression + HDAC recruitment → broad anti-inflammatory; RECOVERY trial: dexamethasone 6mg 10 days → MACE 23% vs 26% in oxygen-requiring COVID-19 (RR 0.64); harm in non-oxygen-requiring (RR 1.19, viral phase); CRS Grade 3-4: methylprednisolone 1-2mg/kg/day IV
Its connections at a glance
Each dot is a concept directly linked to Corticosteroid. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID I010 · concept status: established. Select any connection above to inspect evidence for that specific link.