Molecule
IL-23
Supports effector/pathogenic Th17 biology in multiple inflammatory settings.
Also called: interleukin-23, IL-23, IL23, IL-23 p19/p40
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 1 receptor, 1 disease, 1 therapy.
- 3Where it sits: signalling, response, target on the 15-step immune chain.
What it does
Th17 maintenance/RENEWAL (not just generation, IL-6+TGF-β generates Th17; IL-23 maintains/renews them → anti-IL-23 has superior durability vs anti-IL-17A); SEQUENCE trial (2023): risankizumab vs ustekinumab in CD → 45% vs 33% remission.
Its connections at a glance
Each dot is a concept directly linked to IL-23. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M005 · concept status: established. Select any connection above to inspect evidence for that specific link.