Receptor
BCR
B cell receptor: membrane-bound immunoglobulin (IgM initially, class-switched after GC) + Igα/Igβ signalling subunits.
Also called: B cell receptor, surface immunoglobulin, sIg
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 cell, 2 pathway.
- 3Where it sits: recognition on the 15-step immune chain.
What it does
BCR signalling → BTK → NF-κB; BTK inhibitors (ibrutinib, zanubrutinib, acalabrutinib) approved for B-NHL/CLL/WM; BCR diversity enables antibody response to any antigen shape
Its connections at a glance
Each dot is a concept directly linked to BCR. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID R015 · concept status: established. Select any connection above to inspect evidence for that specific link.