Pathway
Thymic selection & central tolerance
Positive/negative selection of thymocytes; AIRE drives self-antigen expression in thymic epithelium.
In short
- 1What it is: a pathway in foundations.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 cell, 1 tissue, 1 disease.
- 3Where it sits: recognition on the 15-step immune chain.
What it does
AIRE mutations → APECED/APS-1.
Its connections at a glance
Each dot is a concept directly linked to Thymic selection & central tolerance. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P023 · concept status: established. Select any connection above to inspect evidence for that specific link.