Disease
Melanoma
Malignant melanoma shaped by tumour immune recognition and immune escape.
Also called: melanoma, malignant melanoma, cutaneous melanoma
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 1 cell, 1 receptor, 1 biomarker.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
High TMB (UV-induced mutation burden → many neoantigens → TIL-rich); dominant checkpoint: PD-1 axis; KEYnote-006: pembrolizumab vs ipilimumab → 5yr OS 38.7% vs 31.1%; nivo+ipi (CheckMate-067): 5yr OS 52%; WNT/β-catenin activation in 25-35% → cold tumour → anti-PD-1 non-response; KEYnote-942: mRNA-4157 neoantigen vaccine + pembrolizumab RFS HR 0.561
Its connections at a glance
Each dot is a concept directly linked to Melanoma. Colours show the kind of concept.
Sources & evidenceloading…
Loading reviewed sources…
Graph ID D012 · concept status: established. Select any connection above to inspect evidence for that specific link.