Cell
Exhausted CD8 T cell
Chronic antigen drives a TOX-dependent state with high PD-1/TIM-3/LAG-3 and low effector function; TCF1+ progenitor-exhausted cells sustain the pool.
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 0 and is affected by 4 concepts — mostly 1 cell, 1 molecule, 1 pathway.
- 3Where it sits: failure on the 15-step immune chain.
What it does
The TCF1+ progenitor-exhausted subset is the main population that expands after PD-1 blockade.
Its connections at a glance
Each dot is a concept directly linked to Exhausted CD8 T cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C027 · concept status: established. Select any connection above to inspect evidence for that specific link.