Cell
Monocyte
Circulating myeloid cell that can enter tissues and differentiate.
Also called: circulating monocyte
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 2 and is affected by 2 concepts — mostly 1 cell, 1 molecule, 1 pathway.
- 3Where it sits: trigger, response on the 15-step immune chain.
What it does
Monocyte-derived macrophages are dominant IL-6 producers in CAR-T CRS (not T cells, explains why tocilizumab not steroids is first-line); CSF-1R on monocyte-derived macrophages = target of axatilimab (cGVHD FDA 2024)
Its connections at a glance
Each dot is a concept directly linked to Monocyte. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C002 · concept status: established. Select any connection above to inspect evidence for that specific link.