Disease
Multiple sclerosis
Immune-mediated CNS disease involving inflammatory and adaptive immune mechanisms.
Also called: MS, multiple sclerosis, demyelinating disease
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 0 and is affected by 7 concepts — mostly 2 pathway, 1 tissue, 1 pathogen.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
RRMS: CD4+ Th1/Th17 breach BBB (VLA-4/VCAM-1 → natalizumab); Progressive: B cell leptomeningeal aggregates drive compartmentalised CNS inflammation (ORATORIO: ocrelizumab → first positive PPMS trial; proves B cells not T cells drive PPMS); EBV causal factor (Bjornevik Science 2022: 32× risk increase, 5yr lag → EBV vaccine Phase 1 for MS prevention 2025)
Its connections at a glance
Each dot is a concept directly linked to Multiple sclerosis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D002 · concept status: established. Select any connection above to inspect evidence for that specific link.