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Cell

Th17 cell

Barrier defence and inflammatory responses; supports neutrophil-associated immunity.

Also called: Th17 cell, T helper 17

Ask about Th17 cell See in graph Sources

In short

  1. 1What it is: a cell in cells and organs.
  2. 2How it connects: acts on 5 and is affected by 3 concepts — mostly 2 cell, 3 molecule, 1 disease.
  3. 3Where it sits: response, failure, target on the 15-step immune chain.

What it does

IL-17A → neutrophil recruitment, keratinocyte hyperproliferation; AS entheseal inflammation; IBD mucosal; RORγt master TF; maintained by IL-23 (not IL-6+TGF-β which generates Th17, IL-23 renews them); absolute contraindication: anti-IL-17A worsens active IBD (IL-17A essential for gut epithelial tight junctions)

Its connections at a glance

Each dot is a concept directly linked to Th17 cell. Colours show the kind of concept.

Naive CD4 T cellSegmented filamentous…STAT3 loss-of-functio…IL-17ANeutrophilCandida albicansGM-CSFIL-22Th17 cell

Learn next

Comes beforeNaive CD4 T cellCellComes beforeSegmented filamentous bacteria (SFB)PathogenComes beforeSTAT3 loss-of-function (Hyper-IgE / Job)DiseaseLeads toNeutrophilCell
Sources & evidenceloading…

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Graph ID C013 · concept status: established. Select any connection above to inspect evidence for that specific link.