Receptor
NLRP3
Inflammasome sensor responding to diverse cellular danger signals.
Also called: NLRP3 sensor, cryopyrin, NALP3
In short
- 1What it is: a receptor in foundations.
- 2How it connects: acts on 2 and is affected by 0 concepts — mostly 1 pathway, 1 disease.
- 3Where it sits: trigger, signalling on the 15-step immune chain.
What it does
Danger sensor for uric acid crystals/cholesterol crystals/silica/ATP/K+ efflux; activates NLRP3 inflammasome complex → IL-1β + pyroptosis; CAPS (gain-of-function mutations); gout; atherosclerosis
Its connections at a glance
Each dot is a concept directly linked to NLRP3. Colours show the kind of concept.
Sources & evidenceloading…
Loading reviewed sources…
Graph ID R004 · concept status: established. Select any connection above to inspect evidence for that specific link.