Receptor
CTLA-4
Cytotoxic T lymphocyte antigen 4: constitutively expressed on Tregs; upregulated on activated effector T cells.
Also called: cytotoxic T lymphocyte antigen 4, CD152
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 3 concepts — mostly 2 cell, 1 molecule, 1 receptor.
- 3Where it sits: recognition, response, target on the 15-step immune chain.
What it does
Ipilimumab (IgG1 Fc-active → macrophage ADCC depletes tumour Tregs, primary anti-tumour mechanism, not co-stimulation blockade); tremelimumab (IgG2, poor ADCC, inferior as monotherapy).
Its connections at a glance
Each dot is a concept directly linked to CTLA-4. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID R013 · concept status: established. Select any connection above to inspect evidence for that specific link.