Disease
Asthma
Heterogeneous airway disease; type-2 biology is important in many phenotypes.
Also called: asthma, bronchial asthma, severe asthma
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 8 concepts — mostly 2 cell, 1 molecule, 1 pathway.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Heterogeneous: type-2 (eosinophilic, IL-5/IL-13 driven, responds to dupilumab/mepolizumab) vs non-type-2 (IL-5-low, ILC2-driven); tezepelumab (anti-TSLP) effective across ALL endotypes (NAVIGATOR: 56% exacerbation reduction even in low-eosinophil asthma, endotype-agnostic); asthma + IBD overlap → avoid anti-IL-17A
Its connections at a glance
Each dot is a concept directly linked to Asthma. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D005 · concept status: established. Select any connection above to inspect evidence for that specific link.