Molecule
IL-12
Promotes Th1/NK-associated IFN-γ responses.
Also called: interleukin-12, IL-12, IL12
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 2 and is affected by 0 concepts — mostly 1 cell, 1 receptor.
- 3Where it sits: signalling, response on the 15-step immune chain.
What it does
DC-produced Th1 polarising cytokine (IL-12 → IL-12R → JAK2/TYK2 → STAT4 → T-bet → IFN-γ); shared p40 subunit with IL-23 → both blocked by ustekinumab; IL-12 deficiency → susceptibility to non-tuberculous mycobacteria; anti-IL-23 p19 inhibitors (risankizumab) spare IL-12 → preserve Th1/antimycobacterial immunity
Its connections at a glance
Each dot is a concept directly linked to IL-12. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID M004 · concept status: established. Select any connection above to inspect evidence for that specific link.