Disease
Atopic dermatitis
Inflammatory skin disease with type-2 biology in many patients.
Also called: AD, atopic dermatitis, eczema
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 4 concepts — mostly 1 molecule, 2 pathway, 1 tissue.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
FLG mutation → skin barrier defect → epicutaneous sensitisation; IL-4/IL-13/IL-31 Th2 axis; atopic march (AD → food allergy → asthma); dupilumab (anti-IL-4Rα): SOLO 1/2 EASI-75 38% vs 10%; conjunctivitis SE (10-28%) = IL-4/13 regulate ocular goblet cells → mechanistic prediction; upadacitinib (JAK1) + tralokinumab (anti-IL-13) alternatives
Its connections at a glance
Each dot is a concept directly linked to Atopic dermatitis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D006 · concept status: established. Select any connection above to inspect evidence for that specific link.