Immune Super IntelligenceWhere Immunology Meets Advanced AIExplore the Immune System
Receptor

PD-L1

Programmed Death Ligand 1: upregulated on tumour cells (oncogenic EGFR/KRAS/PI3K/MYC → STAT3 → PD-L1) and by adaptive immune resistance (TIL IFN-γ → JAK1/2 → STAT1 → PD-L1).

Also called: programmed death ligand 1, CD274, B7-H1

Ask about PD-L1 See in graph Sources

In short

  1. 1What it is: a receptor in molecules and receptors.
  2. 2How it connects: acts on 1 and is affected by 3 concepts — mostly 2 cell, 1 disease, 1 biomarker.
  3. 3Where it sits: failure, target on the 15-step immune chain.

What it does

PD-L1 TPS/CPS used as predictive biomarker: TPS ≥50% → pembrolizumab monotherapy NSCLC (KEYnote-024); CPS ≥10 → TNBC, gastric, HNSCC.

Its connections at a glance

Each dot is a concept directly linked to PD-L1. Colours show the kind of concept.

Cancer immune escapePD-L1 expressionTumour cellCD8 cytotoxic T lymph…PD-L1

Learn next

Comes beforeCancer immune escapeDiseaseComes beforePD-L1 expressionBiomarkerComes beforeTumour cellCellLeads toCD8 cytotoxic T lymphocyteCell
Sources & evidenceloading…

Loading reviewed sources…

Graph ID R012 · concept status: established. Select any connection above to inspect evidence for that specific link.