Therapy
Ustekinumab
Monoclonal antibody targeting the shared p40 subunit of IL-12 and IL-23.
Also called: ustekinumab, Stelara, UST
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a therapy in therapies and applications.
- 2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 molecule.
- 3Where it sits: therapy on the 15-step immune chain.
What it does
Human IgG1κ; anti-p40 (shared subunit of IL-12 and IL-23) → blocks both; quarterly SC maintenance; psoriasis, PsA, CD, UC; SEQUENCE trial: risankizumab (selective anti-IL-23 p19) > ustekinumab in CD; HLA-Cw*06 positive patients may respond better (PSOLAR data); F.
Its connections at a glance
Each dot is a concept directly linked to Ustekinumab. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID I005 · concept status: established. Select any connection above to inspect evidence for that specific link.