Molecule
IL-1β
Inflammatory cytokine involved in fever and local inflammatory responses.
Also called: IL-1β, interleukin-1 beta, interleukin-1β
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 4 and is affected by 6 concepts — mostly 1 cell, 2 pathway, 3 disease.
- 3Where it sits: signalling, consequence, target on the 15-step immune chain.
What it does
NLRP3 caspase-1 cleaves pro-IL-1β → active form; gout (uric acid crystals → NLRP3 → IL-1β → acute joint inflammation → colchicine/canakinumab); CANTOS trial (N=10,061): canakinumab MACE -15% HR 0.85, LDL unchanged → first clinical proof macrophage NLRP3-IL-1β causally drives CVD; lung cancer -77% unexpected finding
Its connections at a glance
Each dot is a concept directly linked to IL-1β. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M002 · concept status: established. Select any connection above to inspect evidence for that specific link.