Disease
Tuberculosis
Mycobacterial infection in which macrophage and granuloma biology are central.
Also called: TB, tuberculosis, MTB infection
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 3 concepts — mostly 1 cell, 1 molecule, 2 therapy.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
IFN-γ → macrophage activation → intracellular killing essential; TNF maintains granuloma integrity (anti-TNF → granuloma dissolution → reactivation TB, 40× risk with anti-TNF vs general population → mandatory LTBI screening); IL-12 deficiency → disseminated non-tuberculous mycobacteria
Its connections at a glance
Each dot is a concept directly linked to Tuberculosis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D010 · concept status: established. Select any connection above to inspect evidence for that specific link.