Molecule
PD-L2
Programmed Death Ligand 2: second PD-1 ligand (lower expression than PD-L1); predominantly on APCs (DCs, macrophages); IL-4 induces PD-L2 expression (Th2 context, different from PD-L1 which is IFN-γ-inducible in Th1/TME).
Also called: B7-DC, PDCD1LG2
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a molecule in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 receptor.
- 3Where it sits: failure on the 15-step immune chain.
What it does
Less clinically targeted than PD-L1; anti-PD-1 blocks both PD-L1 and PD-L2 interactions (vs anti-PD-L1 drugs which only block PD-L1/PD-1); anti-PD-L2 ICI not yet clinically developed
Its connections at a glance
Each dot is a concept directly linked to PD-L2. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID M019 · concept status: established. Select any connection above to inspect evidence for that specific link.