Cell
Tfh cell
Provides B-cell help in follicles and germinal centres.
Also called: Tfh, T follicular helper, CXCR5+PD-1+CD4+
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 4 and is affected by 1 concepts — mostly 1 cell, 2 molecule, 1 pathway.
- 3Where it sits: response, failure on the 15-step immune chain.
What it does
GC B cell help → SHM → affinity maturation → class switching → high-affinity IgG; circulating Tfh (cTfh: CXCR5+PD-1+CD4+) correlates with SLE disease activity and independently predicts LN flares; autoreactive GC driven by Tfh in SLE → anti-dsDNA IgG production
Its connections at a glance
Each dot is a concept directly linked to Tfh cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C016 · concept status: established. Select any connection above to inspect evidence for that specific link.