Pathway
Th17 differentiation
Differentiation programme involving IL-6/TGF-β and IL-23 support.
Also called: Th17 differentiation, Th17 polarisation, RORγt pathway
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 0 and is affected by 2 concepts — mostly 1 receptor, 1 disease.
- 3Where it sits: signalling, response on the 15-step immune chain.
What it does
IL-6+TGF-β→RORγt (generation); IL-23→IL-23R→STAT3→RORγt stabilisation (maintenance/renewal, the therapeutic difference between anti-IL-17A and anti-IL-23 durability profiles); drives psoriasis, AS, IBD mucosal inflammation
Its connections at a glance
Each dot is a concept directly linked to Th17 differentiation. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P010 · concept status: established. Select any connection above to inspect evidence for that specific link.