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Pathogen

Mycobacterium tuberculosis

Intracellular pathogen associated with granulomatous inflammation.

Also called: MTB, M. tuberculosis, Mycobacterium tuberculosis

Ask about Mycobacterium tuberculosis See in graph Sources

In short

  1. 1What it is: a pathogen in diseases and immunopathology.
  2. 2How it connects: acts on 0 and is affected by 4 concepts — mostly 1 cell, 1 molecule, 1 pathway.
  3. 3Where it sits: trigger on the 15-step immune chain.

What it does

Intracellular pathogen evading phagolysosomal killing; requires IFN-γ-driven macrophage M1 activation + TNF-driven granuloma containment; TNF essential → anti-TNF → 40× TB reactivation risk → mandatory LTBI screening (IGRA) before ANY biologic; rifampicin enzyme inducer → drug interactions with DMARDs

Its connections at a glance

Each dot is a concept directly linked to Mycobacterium tuberculosis. Colours show the kind of concept.

MacrophageComplement C3Colonisation resistan…IL-12/IFN-γ axis defe…Mycobacterium tuberculosis

Learn next

Comes beforeMacrophageCellComes beforeComplement C3MoleculeComes beforeColonisation resistancePathway
Sources & evidenceloading…

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Graph ID X001 · concept status: established. Select any connection above to inspect evidence for that specific link.