Disease
Psoriasis
Chronic inflammatory skin disease with important IL-23/IL-17-axis biology.
Also called: psoriasis, plaque psoriasis
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 1 and is affected by 7 concepts — mostly 1 cell, 4 molecule, 1 pathway.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
Th17/ILC3 → IL-17A → keratinocyte hyperproliferation; pDC LL-37/DNA complex → TLR9 → IFN-α → DC → Th17 amplification; HLA-Cw*06 (45-67% of patients, predicts ustekinumab response); IL-23 p19 inhibitors show superior PASI 90 durability (>70% at 5yr) vs IL-17A inhibitors; bimekizumab (anti-IL-17A+F dual) highest PASI 100 rates (67% at week 16)
Its connections at a glance
Each dot is a concept directly linked to Psoriasis. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D003 · concept status: established. Select any connection above to inspect evidence for that specific link.