Cell
Myeloid-derived suppressor cell
Immature myeloid cells expanded in cancer and chronic inflammation that suppress T cells via arginase-1, iNOS, ROS and IL-10.
In short
- 1What it is: a cell in cells and organs.
- 2How it connects: acts on 2 and is affected by 0 concepts — mostly 1 molecule, 1 tissue.
- 3Where it sits: failure on the 15-step immune chain.
What it does
High circulating MDSC levels associate with poorer checkpoint-inhibitor outcomes in several cancers.
Its connections at a glance
Each dot is a concept directly linked to Myeloid-derived suppressor cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C025 · concept status: evidence-supported. Select any connection above to inspect evidence for that specific link.