Pathway
NLRP3 inflammasome
Inflammasome pathway supporting maturation of IL-1β and IL-18.
Also called: NLRP3, NLRP3 inflammasome, cryopyrin inflammasome
In short
- 1What it is: a pathway in signalling and mechanisms.
- 2How it connects: acts on 4 and is affected by 3 concepts — mostly 3 molecule, 1 receptor, 1 disease.
- 3Where it sits: trigger, signalling, target on the 15-step immune chain.
What it does
Activated by uric acid crystals (gout), cholesterol crystals (atherosclerosis), silica (occupational autoimmunity), ATP, K+ efflux; NLRP3+ASC+caspase-1 → IL-1β+IL-18+pyroptosis; colchicine (blocks NLRP3 assembly + NETs; COLCOT: MACE -23%; LoDoCo-2: MACE -31%); MCC950/dapansutrile (direct NLRP3 inhibitors Phase 2); CAPS (NLRP3 gain-of-function → autoinflammatory disease)
Its connections at a glance
Each dot is a concept directly linked to NLRP3 inflammasome. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID P003 · concept status: established. Select any connection above to inspect evidence for that specific link.