Disease
Type 1 diabetes
Immune-mediated destruction of pancreatic beta cells: CD8+ CTL (nPOD histology dominant) + CD4+ Th1 + macrophage insulitis → beta cell death → absolute insulin deficiency.
Also called: T1DM, type 1 diabetes mellitus, juvenile diabetes, autoimmune diabetes
In short
- 1What it is: a disease in diseases and immunopathology.
- 2How it connects: acts on 0 and is affected by 4 concepts — mostly 1 cell, 1 pathway, 1 therapy.
- 3Where it sits: failure, disease on the 15-step immune chain.
What it does
TN10 TEPLIZUMAB TRIAL (2019/FDA 2022): anti-CD3 Fc-silent → Th1:Treg ratio shift in islets → T1DM onset delayed 25 months (HR 0.41, p=0.006), the first drug shown to delay an autoimmune disease.
Its connections at a glance
Each dot is a concept directly linked to Type 1 diabetes. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID D013 · concept status: established. Select any connection above to inspect evidence for that specific link.