Cell
Plasmacytoid dendritic cell
Specialized innate cell capable of strong type-I interferon production.
Also called: pDC, plasmacytoid DC
In short
- 1What it is: a cell in foundations.
- 2How it connects: acts on 2 and is affected by 1 concepts — mostly 1 receptor, 2 pathway.
- 3Where it sits: signalling, failure, target on the 15-step immune chain.
What it does
Produces 1000× more IFN-α per cell than other cells; NET DNA/LL-37 complexes → TLR7/9 → massive IFN-α → SLE interferon signature (75% of patients); drives BAFF production from monocytes; downstream target: anifrolumab (anti-IFNAR1 FDA 2021 SLE)
Its connections at a glance
Each dot is a concept directly linked to Plasmacytoid dendritic cell. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID C005 · concept status: established. Select any connection above to inspect evidence for that specific link.