Receptor
TLR4
Recognizes bacterial lipopolysaccharide in cooperation with accessory molecules.
Also called: toll-like receptor 4, TLR4, CD284
Sparsely connected — only 1 link recorded so far.
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 0 concepts — mostly 1 pathway.
- 3Where it sits: trigger, recognition on the 15-step immune chain.
What it does
LPS sensor (with MD-2+CD14 co-receptors) → MyD88→IRAK4→TRAF6→NF-κB AND TRIF→TBK1→IRF3→IFN-β; most clinically relevant TLR in sepsis (LPS-driven systemic inflammation); gut TLR4 constitutively suppressed to tolerate commensal LPS
Its connections at a glance
Each dot is a concept directly linked to TLR4. Colours show the kind of concept.
Learn next
Sources & evidenceloading…
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Graph ID R001 · concept status: established. Select any connection above to inspect evidence for that specific link.