Receptor
TNFR1
TNF receptor capable of inflammatory and cell-death signalling.
Also called: TNF receptor 1, TNFR1, CD120a, p55 TNFR
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 1 concepts — mostly 1 molecule, 1 pathway.
- 3Where it sits: signalling, consequence on the 15-step immune chain.
What it does
Ubiquitous expression; death domain → apoptosis; TRADD→TRAF2→NF-κB (survival); drives pro-inflammatory signalling; dominant receptor for soluble TNF; target of anti-TNF therapy (blocks TNFR1 engagement)
Its connections at a glance
Each dot is a concept directly linked to TNFR1. Colours show the kind of concept.
Sources & evidenceloading…
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Graph ID R005 · concept status: established. Select any connection above to inspect evidence for that specific link.