Receptor
IL-23R
Receptor component mediating IL-23 signalling.
Also called: IL-23 receptor, IL-23R, interleukin-23 receptor
In short
- 1What it is: a receptor in molecules and receptors.
- 2How it connects: acts on 1 and is affected by 2 concepts — mostly 2 molecule, 1 pathway.
- 3Where it sits: signalling, response, target on the 15-step immune chain.
What it does
IL-23R+IL-12Rβ1 → JAK2/TYK2 → STAT3 → RORγt stabilisation (Th17 renewal); IL-23R variants associate with IBD, AS, psoriasis (GWAS); guselkumab, risankizumab (anti-IL-23 p19) block IL-23 before receptor engagement
Its connections at a glance
Each dot is a concept directly linked to IL-23R. Colours show the kind of concept.
Sources & evidenceloading…
Loading reviewed sources…
Graph ID R009 · concept status: established. Select any connection above to inspect evidence for that specific link.